The non-coding genome, once dismissed as "junk DNA", is now recognized as a fundamental regulator of gene expression and a key player in understanding complex diseases. Following the landmark ...

Chemotherapeutic resistance is a significant issue in the treatment of breast cancer, which is related to pyroptosis inhibition. Increasing evidence suggests that long non-coding RNAs (lncRNAs) ...

Long non-coding RNAs (lncRNAs) have emerged as pivotal regulators of gene expression across various levels, including transcriptional, post-transcriptional, and epigenetic mechanisms. In pediatric ...

A research team from National Taiwan University, Academia Sinica, and National Taiwan University Hospital has uncovered a critical connection between a unique RNA molecule and human aging, including ...

Researchers have revealed that so-called ‘junk DNA’ contains powerful switches that help control brain cells linked to Alzheimer’s disease. When people picture DNA, they often imagine a set of genes ...

Only around two percent of the human genome codes for proteins, and while those proteins carry out many important functions of the cell, the rest of the genome cannot be ignored. However, for decades ...

"With up to half of individuals with rare diseases currently living without a diagnosis, exploring the non-coding DNA can provide answers for families with rare conditions." The researchers found that ...

A rapidly advancing area of biomedical innovation is shining a spotlight on miR-128-3p, a small yet powerful molecule with the potential to reshape how diseases—especially cancer—are detected, ...

When AlphaFold solved the protein-folding problem in 2020, it showed that artificial intelligence could crack one of biology’s deepest mysteries: how a string of amino acids folds itself into a ...

What keeps our cells the right size? Scientists have long puzzled over this fundamental question, since cells that are too large or too small are linked to many diseases. Until now, the genetic basis ...

Scientists have found new genetic causes for diabetes in babies – in a part of the genome that has historically been overlooked in genetic studies. Until recently, most research has investigated ...