Nature

Riboformer: a deep learning framework for predicting context-dependent translation dynamics

Translation elongation is essential for maintaining cellular proteostasis, and alterations in the translational landscape are associated with a range of diseases. Ribosome profiling allows detailed ...
Nature

Comprehensive profiling of clinically approved kinase inhibitors reveals mutation-specific inhibitors and opportunities for drug repurposing

Protein kinases are central to cell signaling and key drug targets in cancer. To inform potential repurposing of kinase inhibitors, we profiled 86 of the ~100 approved kinase inhibitors against 758 ...
ascopubs.org

Dissecting primary endocrine resistance through ctDNA profiling of a hybrid real-world and clinical trial dataset in hormone receptor-positive, HER2-negative (HR+/HER2 ...

Differences in genomic profiles, targeted treatment use, and overall survival in patients with metastatic breast cancer by Area Deprivation Index. This is an ASCO Meeting Abstract from the 2025 ASCO ...